Progesterone, a widely used steroid drug for the treatment of luteal phase deficiency, has very low water solubility and bioavailability. Cyclodextrin nanosponges are polymer-like materials used to enhance the aqueous solubility and bioavailability of lipophilic drugs. In this study, cyclodextrin nanosponges were synthesized using β-cyclodextrin and hexamethylene diisocyanate as a crosslinker; meanwhile, the complexation of progesterone within the nanosponge was investigated using Fourier transform infrared spectroscopy and X-ray diffraction analyses. Furthermore, the encapsulation efficiency and phase solubility of progesterone were assessed by UV-visible spectroscopy. Characterization techniques confirm the successful formation of the complex. The nanosponge was found to be able to encapsulate 70% of the drug and increase its aqueous solubility approximately 45 times. Moreover, phase solubility studies suggest the formation of a 1:2 (drug:host) molar ratio complex. Moreover, molecular docking simulation confirms the obtained experimental data and ensures the formation of a 1:2 complex by visualizing a hydrogen bond between the drug and host molecules.
Hadadian, M., Mahdavi, B. & Rezaei-Seresht, E. (2025). A Theoretical and Experimental Analysis of the Complexation Process Between Progesterone and Cyclodextrin Nanosponge. (e210145). Journal of Applied Material Science, 1(3), e210145 https://doi.org/10.22034/jams.2025.210145
MLA
Hadadian, M., Mahdavi, B., & Rezaei-Seresht, E. "A Theoretical and Experimental Analysis of the Complexation Process Between Progesterone and Cyclodextrin Nanosponge" .e210145 , Journal of Applied Material Science, 1, 3, 2025, e210145. doi: 10.22034/jams.2025.210145
HARVARD
Hadadian, M., Mahdavi, B., & Rezaei-Seresht, E. (2025). 'A Theoretical and Experimental Analysis of the Complexation Process Between Progesterone and Cyclodextrin Nanosponge', Journal of Applied Material Science, 1(3), e210145. doi: 10.22034/jams.2025.210145
CHICAGO
Hadadian, M., Mahdavi, B. & Rezaei-Seresht, E., "A Theoretical and Experimental Analysis of the Complexation Process Between Progesterone and Cyclodextrin Nanosponge." Journal of Applied Material Science, 1 3 (2025): e210145, doi: 10.22034/jams.2025.210145
VANCOUVER
Hadadian M., Mahdavi B., Rezaei-Seresht E. A Theoretical and Experimental Analysis of the Complexation Process Between Progesterone and Cyclodextrin Nanosponge. J. Appl. Mater. Sci. 2025;1(3):e210145. doi: 10.22034/jams.2025.210145
Journal of Applied Material Science